Method: In line with that, our current study involved screening of potent PTP1B inhibitors from the Natural Product Discovery System (NADI) database using in silico virtual screening and in vitro PTP1B inhibition study. Thus, drugs that are potent to impede this enzyme should be effective in treating T2DM and obesity. Protein tyrosine phosphatase 1B (PTP1B) is thought to interfere with glucose homeostasis and satiety through down-regulation of insulin and leptin signaling pathways. Insulin and leptin resistance are the most common pathophysiological link between T2DM and obesity. Understanding these mechanisms could lead us to manage diabetes more efficiently, thus curtailing its age-related complications. Diabetes has also been proven to be a key cause of premature aging through different mechanisms. Introduction: Growing incidence of type-2 diabetes mellitus (T2DM), together with obesity, shows the complexity and progressive nature of these metabolic disorders and alarms the necessity to explore new and alternative therapeutic pathways and drugs.
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June 2023
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